Reason of Rybelsus Weight Loss

by Adarsh Patel
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Rybelsus weight loss

Rybelsus is a GLP-1 (glucagon-like peptide-1) medicine used to treat adults with type II diabetes mellitus. Rybelsus has helped people in weight loss when they also make changes to their diet and exercise habits.

If you qualify, your doctor may give you Rybelsus to help you to lose weight.

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What is Rybelsus?

Rybelsus is a GLP-1 drug that has been approved by the Food and Drug Administration (FDA) in the US for use in adults with a body mass index (BMI) of over 27 who also have conditions like high blood pressure or high cholesterol, or who are obese (BMI of over 30).

It is a strong selective GLP-1 receptor agonist that has been shown to lower blood sugar levels and feelings of hunger while making people with a high BMI feel fuller.

Rybelsus is one of the weight loss drugs that an Alfie doctor might prescribe to help lose weight or treat a health problem related to weight. It is made by the company Novo Nordisk.

People with a personal or family history of multiple endocrine neoplasia type 2 (MEN 2), people who have had a serious allergic reaction to semaglutide or any other ingredients in Rybelsus, or people who have had pancreatitis in the past should not take Rybelsus.

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How does Rybelsus work?

How does Rybelsus work
How does Rybelsus work

Rybelsus is a GLP-1 receptor agonist, which is a type of medicine. It could also be called a mimic of incretin.

Rybelsus works by doing the same things that the body’s own incretin hormones do, which help keep blood sugar levels in check, especially right after a meal.

Gut peptides called incretin hormones are released from the stomach when food is eaten. In response to high blood glucose levels, they make insulin appear more.

GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 are the names of two different types of incretin hormones (glucagon-like peptide-1).

People with type 2 diabetes don’t make as much or any incretin as they used to. It can, however, be made to work better with drugs like Rybelsus.

People make Rybelsus, but it has 94% of the same structure as GLP-1 made by people. It works like GLP-1 and binds to GLP-1 receptors.

This makes pancreas to produce more insulin and the liver to make less glucagon. This makes a person feel full by slowing the emptying of the stomach.

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Rybelsus used for

Rybelsus is an oral drug used to enhance blood sugar control in persons over 18 with type 2 diabetes. It is frequently recommended after oral medications for diabetes have not worked or have ceased working.

2kg to 4kg weight loss may occur in persons using Rybelsus for type 2 diabetes. Research has shown that after taking Rybelsus, people lost an average of:

  • 5 pounds (2.3kg) when taking Rybelsus 7mg
  • 8.1 pounds (3.7kg) when taking Rybelsus 14mg.
  • People with a greater beginning body weight and those suffering more digestive issues may be more likely to lose weight once therapy with Rybelsus has started.

Rybelsus won’t work in treating type 1 diabetes.

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Rybelsus vs. metformin

Rybelsus is a brand-name drug whose active ingredient is semaglutide. Metformin is a generic version of a drug that works.

Rybelsus vs. Ozempic

Semaglutide is the active ingredient in both Rybelsus and Ozempic, which are both brand-name drugs. Ozempic is given by injection, while Rybelsus is taken by mouth.

Rybelsus Side Effects

Rybelsus Side Effects
Rybelsus Side Effects

When taking Rybelsus, it is possible to have side effects. Most side effects go away after a few days or weeks for most people.

Most of the time, Rybelsus can cause the following side effects:

  • Nausea
  • Pain in the stomach (abdomen)
  • Diarrhea
  • loss of appetite
  • Vomiting
  • Constipation

Rybelsus can cause more serious side effects like:

  • Low sugar in the blood (hypoglycemia)
  • a pancreas that is inflamed (pancreatitis)
  • Serious reactions to allergies
  • Vision changes/vision gets blurry
  • Failed kidneys

If you have serious side effects, you should stop taking Rybelsus immediately and see a doctor. Talk to your doctor immediately about any side effect that bothers you or doesn’t go away.


Q.1. How long does rybelsus take to help you lose weight?

Ans. Rybelsus should be taken slowly, starting with 3 mg once a day. Starting with a lower dose helps your body get used to the medicine and reduces the risk of digestive side effects like nausea, stomach pain, diarrhea, loss of appetite, vomiting, and constipation.

This low dose is taken for 30 days, but it doesn’t work to lower blood sugar levels. After 30 days of taking 3mg of Rybelsus every day, your doctor will increase the dose to 7mg once a day.

This dose usually works to lower blood sugar levels, and it can be increased to 14mg a day after 30 days if it is well tolerated and more blood sugar lowering is wanted.

It’s not a good idea to take two 7mg tablets to get a 14mg dose.

Because Rybelsus is started slowly at a lower-than-effective dose, it won’t work properly until the dose is raised to at least 7mg, which happens after 30 days of taking 3mg. So at least 31 days must pass before it works.

Q.2. Why does rybelsus help you lose weight?

Ans. You may lose weight if you take other diabetes medicines along with Rybelsus. Rybelsus can also make people feel sick, throw up, have diarrhea, and lose their appetite. And because of these side effects, some people may lose weight. Rybelsus may cause weight loss, which may be a good thing.

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